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There is still an ongoing debate on whether the three CTA models are interchangeable or whether there should be criteria guiding the choice of one over the other based on their peculiarities and the characteristics of the tested chemicals ( In the absence of approved test guidelines, the OECD issued two guidance documents endorsing the use of CTA based on SHE and Bhas 42 cells

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doi: 10.1128/mBio.01828-17 270 MayR

Schneider, J