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Following the melatonin PRC and taking the individual DLMO as the reference phase to decide the most suitable time of melatonin administration, according to the desirable effect, seem the most appropriate guide to decide when to start chronic melatonin therapy (98-100)

Kurtzhals, P

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However, it is important to note that these mechanisms are still speculative and require further research

This phenomenon is associated with 35- to 50-fold higher hyaluronan synthase 1 mRNA expression in the outer and inner medulla of the kidney and a sustained increase in hyaluronan synthase 2 mRNA expression