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Suggested cutoffs and the interpretation of values of the combined 4cB12 indicator for use by researchers and clinicians and for epidemiologic purposes are shown in Table 22b.10

This protein is a type II transmembrane glycoprotein encoded on chromosome 4 (4p15.32) and consists of three domains: an intracellular domain (N-terminus) of 21 amino acids, an alpha-helix transmembrane domain and an extracellular domain (C-terminus) of 256 amino acids

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In addition to serum B12, more accurate markers include methylmalonic acid (MMA) and homocysteine levels , especially for people with MTHFR mutations