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COVID-19 viral RNA and antigens have been detected in the cerebrospinal fluid and the brain tissue, indicating that the virus can cross the bloodbrain barrier to invade the central nervous system ( via extracellular vesicles and direct intercellular transmission ( The COVID-19 virus can colonize the brain, leading to neuronal death and inflammation ( COVID-19 can induce cytokine storms and neuroinflammation, leading to neuronal damage and decreased cognitive function

It is found that these two markers started to increase even when B12 level was still above its lower limit of 148 pmol/L (200 pg/L), as such they are considered as more sensitive markers and may help for diagnosis of B12 deficiency

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