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CIT functions as a precursor to L-arginine, thereby facilitating the synthesis of NO through the activation of eNOS, which in turn enhances endothelial functionality, vasodilation, and the perfusion of skeletal muscle (11)

This is the challenge of the ketogenic diet

This enzyme converts L-arginine into nitric oxide and L-citrulline

366 Stem cells and stem cell-derived exosomes have shown immunomodulatory effects on DKD, diabetic cardiomyopathy, DR, and DFU, involving the regulation of macrophage polarization, the inflammatory balance, and Tregs (Table S2)