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During the Krebs cycle, IDH catalyzes the oxidative decarboxylation of isocitrate to -ketoglutarate [-KG, also known as 2-oxyglutarate (2OG)] and reduces the cofactor NADP+ into NADPH which is essential to decrease the level of reactive oxygen species (ROS) (105107)

While many of the findings cited above were observed in animal studies (and therefore cannot be extrapolated to humans), there is evidence that researchers are actively exploring BCP-157s potential in these areas

ER stress can escalate lipid peroxidation, activating ferroptotic pathways