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Taken together, these findings suggest that Nrf2 plays a vital role in mediating the chondroprotective effects of metformin by means of anti-oxidation, and that loss of Nrf2 substantially attenuates, but does not completely abolish, the therapeutic efficacy of metformin in the MIA-induced OA model

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aureus ) [47], prolong the inflammatory phase by stimulating continuous immune activation

Furthermore, we found that as an increasing amount of recombinant IL18R1 (Fig