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On the contrary, Ruminococcaceae members were found to decrease in numbers in fibrosis in MASLD non-obese patients and are responsible for maintaining homeostasis of the gut microbial environment (Table 2)

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7 Outlook The precision management of DS faces critical challenges and opportunities, with future research prioritizing the following frontiers: Retinal-Brain Glial Dynamics as a Diagnostic Window: Building on the potential of non-invasive biomarkers like retinal imaging (e.g., OCT) highlighted for capturing glial activity, future studies should decipher the bidirectional signaling between retinal and brain glial cells (astrocytes, microglia

25 Bartalena L, Robbins J

Addition of Se to L-T4 therapy may be appropriate in patients with low Se intake and mild or early stage HT