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Zempleni, J., Trusty, T

Therapeutic potential of medicinal plants and their phytoconstituents in diabetes, cancer, infections, cardiovascular diseases, inflammation and gastrointestinal disorders

Moreover, inhibition of phosphofructokinase (PFK-1) and PKM2 can drive glycolytic flux toward the PPP, which may also be a major factor involved in the widespread overexpression of PKM2 in cancer cells because of the low catalytic efficiency of PKM2 compared with that of PKM1 [47]