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In tumor cells, the apoptosis pathway is often impeded by various mechanisms, many of which contribute to intrinsic resistance to chemotherapy, the most prevalent anticancer therapy (104)

Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients

In PDAC, DON and its prodrug DRP-104 were found to arrest tumor proliferation and reduce metastasis in various mouse models [6]

And so a lot of people think that, like, if their mitochondrial function is declining, they should feel tired all the time, but thats not necessarily the case