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pH-sensitive targets The tumor microenvironment and intracellular compartments like endosomes and lysosomes often exhibit a lower pH, which can be exploited by pH-sensitive nanocomposites for targeted drug release [136]

As reported in Table 1, among the analyzed tumor types, CRC shows the highest number of preclinical studies on DNA methylation ( N = 24), including 16 diagnostic and eight prognostic studies

Oral mucosal organoids as a potential platform for personalized cancer therapy

A.Borromeo-AustinC.HebrokM

Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 instead of alpha5beta1 integrin