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In the original 2015 Cell Metabolism paper, MOTS-c activated AMPK, improved insulin sensitivity in diet-induced obese mice, and reduced age-related insulin resistance in older animals [2]

Vitamin B12 is found mostly in animal products, including meats, seafood, dairy products, and eggs

doi: 10.1126/science.1254721 27 FranklinJLMcManusMJMurphyMP

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