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Diagnosis of cats in cohort 2 was based on renal pathology findings, including assessments on global glomerulosclerosis, fibrosis, inflammation, and tubular atrophy, by a board-certified nephropathologist at a veterinary renal pathology laboratory (Columbus, OH), available health history, as well as clinical observations

Survivals have very small brains (60% of normal size) but remain morphologically normal[85]

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Gaussian accelerated Molecular Dynamics (GaMD) simulations also show that this loop is flexible when NSD2 is absent but is restricted when NSD2 is bound (Supplementary Movie 1 and Supplementary Figs