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This gene variation negatively impacts carnitine transport across the blood-brain barrier (in males and not females), preventing the synthesis of a carnitine precursor called trimethyllysine

That makes so much sense

The ROS concentration of neutrophils in the induced sputum samples and the 8-iso-PGF2 concentration in the peripheral blood samples were higher in the severe asthma group ( P = 0.012

see also Sneeboer et al., 2019), all of which represent urgent clinical targets for intervention

Low levels correlate with the progression of coronary artery disease, which was observed not only in individuals with coronary artery obstructions that required intervention but also in people who were relatively young and apparently healthy