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Importantly, these signals were completely abolished by PARPi treatment

Peng et al., 2015

DOI: 10.1021/acs.jcim.0c00025 19

Thank you Oasis IV

proposed a model to demonstrate that the levels of NAMPT and NAD+ in hippocampal neurons, particularly in CA1 neurons, decline during aging, leading to a decrease in SIRT1 activity and subsequent downregulation of Cask expression in the aged hippocampus