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Pathophysiology of inflammatory bowel disease: innate immune system

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Cava E, Fontana L

Recently, a number of senolytic agents such as dasatinib and quercetin (DQ) 9 , ABT-263/737 10 , HSP90 inhibitor 11 , cardiac glycoside 12 and procyanidin C1 13 have been discovered and demonstrated promising results in both pre-clinical and clinical trials

From a mechanistic standpoint, glutathione participates in: Neutralization of reactive oxygen species Recycling of other antioxidants such as vitamin C and vitamin E Phase II metabolic pathways Regulation of protein structure through thiol group maintenance Cellular signaling related to immune modulation Mitochondrial energy processes These overlapping roles help explain why glutathione appears frequently in discussions of chronic oxidative burden and inflammatory stress patterns