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An initial proof-of-concept phase 2 trial provided first disease-modifying efficacy signals of exenatide (see Table 4) but was limited by its single-blind design [188]

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Abstract Microspore embryogenesis (ME) relies on the cellular reprogramming of the default gametophytic developmental pathway, which normally directs microspores toward pollen formation, into an embryogenic pathway that leads to the development of embryolike structures (ELS) and, subsequently, haploid or doubled haploid (DH) plants

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