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Moreover, pachymic acid inhibits hexokinase II and promotes the detachment of hexokinase II from mitochondria, thereby inhibiting glycolysis and initiating the mitochondrial apoptotic pathway [191]

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These limitations in the field highlight a need for systematic and standardized research to reliably assess and translate pharmacological interventions from ASD animal models to human clinical relevance

Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes