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Third, microbiota-dependent and microbiota-independent mechanisms should be disentangled using targeted mechanistic designs, for example, antibiotic depletion, fecal microbiota transplantation, gnotobiotic or defined-consortium models, and metabolite supplementation, supported by paired multiomics that link microbial functions and metabolites to host pathways

The enzyme was purified by affinity chromatography using Glutathione-Sepharose 4B column (Cat.#17075601)

Participants on the 5mg dose lost an average of 16.0% of their body weight

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Higher therapeutic doses require a more concentrated formulation or multiple injections per session