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More help Evidence Assessment Addressess the biological plausibility, empirical support, and quantitative understanding from each KER in an AOP

In contrast to their protein-bound counterpart, FAAs can interact with specific receptors present on a wide variety of cells in various parts of the body, including the intestines, where they can activate specific intracellular pathways and confer physiological effects (34, 48)

89 Resistance due to Inactivation by Glutathione or GSTs Intracellular inactivation of alkylating agents has been implicated in human tumor resistance

Therefore, the relatively low abundance of lipoylation in untreated cells suggests that lipoylation is rate-limiting for the OGDHc, and our findings are consistent with the accumulation of Lp glu following ABHD11 inhibition, which reduces OGDHc activity (Fig