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3.3 Defective mitochondrial biogenesis Maintaining an adequate pool of functional neural mitochondria and restoring those that have been damaged or lost relies on mitochondrial biogenesis

Possibly, this toxicity, in addition to lower esophageal sphincter and pyloric sphincter failure, involves sole NSAIDs-gastric ulcers, presenting with aspirin (and thereby, aspirin was used intragastrically) (14) and ibuprofen (10), as well as with those agents combining gastric and small intestine ulcers (i.e., diclofenac (9, 11))

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Methylcobalamin helps reduce homocystein concentration by converting homocysteine to methionine through a methylation process