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Felger, 2018

2020;15:e0239506

Animal models of hearing loss and human clinical trials are actively testing a strategy that combines antioxidant treatments to deliver better ROS scavenging (Gilles et al

96 Moreover, this landmark study proposed for the first time that PGC-1 activity is dually regulated by AMPK through direct phosphorylation and SIRT1-mediated deacetylation, synergistically enhancing its downstream transcriptional control of autophagy

After PEG modification, it can not only bind closely to albumin, cover the enzymatic hydrolysis site of DPP-4, but also reduce renal excretion, prolong the biological half-life, and achieve the effect of long circulation