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The massive accumulation of ROS can directly damage the biomacromolecules of nerve cells, such as causing lipid peroxidation of cell membranes, damaging mitochondrial DNA and proteins, and leading to oxidative modifications of nucleic acids, thereby destroying the structural and functional integrity of cells, ultimately inducing apoptosis or necrosis (Lee et al., 2014)

Nat Immunol (2021) 22:26

from 12 to 12.1 min, returning from 98% to 2% B

Immune Netw 25(1):e6 Zhou R et al (2025) Sulfasalazine combined with anti-IL-1 mAb induces ferroptosis and immune modulation in oral squamous cell carcinoma

The practical limitation is its short half-life requiring daily dosing and producing a relatively modest GH pulse compared to the CJC-1295/ipamorelin combination