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Indeed, under hypoxic conditions, elephant seals upregulated expression of several genes along the GSH metabolic pathway, some of which also play a role in polyamine synthesis

In the context of FPN deficiency or inadequate expression, the cells cannot efficiently export iron, resulting in continued accumulation of free iron and further enhancing the detrimental effects of ferroptosis

It is also worth investigating whether the supplementation of with I 2 -Q 10 restores respiratory function in a CoQ-deficient cell culture model, as some CoQ derivatives suffer from a loss of function upon modification of the tail (e.g., Mito-Q)

On the therapeutic front, alongside novel drug delivery strategies like levodopa inhalation powder and continuous subcutaneous infusions [8], disease-modifying therapies targeting specific molecules such as -syn and c-Abl, as well as cutting-edge approaches like immunotherapy, stem cell therapy, and gene therapy, have shown considerable potential

Nature 492:123127 Frahm J, Merboldt KD, Hanicke W (1987) Localized proton spectroscopy using stimulated echoes