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Furthermore, among non-tobacco smokers, exposure to electronic cigarettes resulted in a decrease in forced expiratory flow at 75% (FEF75), indicating that nicotine-free ECs do not produce significant short-term changes in lung functions in non-smokers but have small effects on different lung functions in tobacco smokers ( 1 /FVC, FVC, PEF, FEF 25 - 75 ), an increase in exhaled carbon monoxide (CO), and serum nicotine, and a decrease in exhaled fraction of nitric oxide (FeNO), although these values were lower than those found in regular tobacco users ( Regarding long-term effects in the general population with a history of smoking, a controlled 1-year follow-up study found that changes in exhaled nitric oxide (FeNO) were significantly correlated with those of exhaled carbon monoxide (COe) throughout the follow-up, mainly a relative increase in the first 3 months followed by a significant increase at 6 and 12 months ( Regarding short-term respiratory symptoms, Dicpinigaitis et al

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