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49 In the future, hypoxia-directed treatment may evolve from the use of hypoxic cell cytotoxins to targeted drugs that exploit cellular signaling changes induced by hypoxia such as hypoxia-inducible factor 1 (HIF-1)

Cancer immunotherapy for the immunosuppressed: dissecting the conundrum of safety and efficacy

The gray scale value of protein bands was scanned using Image Lab5.0 (Biorad, Hercules, CA, USA)

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Many such programs are underway worldwide, and are addressing issues relating to infancy, childhood, parents and the community, and through international networks