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Although this practice is common across biomedical research, it has unintended consequence of systematically removing female-specific biological variability from the evidence base

Cystine uptake determined the sensitivity of acute myeloid leukemia cells to APR-246 Since cysteine is a biosynthetic precursor of GSH, we asked whether the ability of cells to provide cysteine for GSH synthesis underlies the sensitivity to APR-246

The binding of the ethacrynic acid-glutathione conjugate shows that the contacts of the glutathione moiety with the protein are identical to those observed in crystal structures of the enzyme with other glutathione-based substrates and inhibitors

Precision medicine and radiogenomics in breast cancer: new approaches toward diagnosis and treatment

Paredes SD, Marchena AM, Bejarano I, et al