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NCOA4 is primarily regulated at the post-translational level, involving dual degradation pathways: Autophagy, particularly through its role in ferritinophagy (79,84), and proteasomal degradation, which is facilitated by the E3 ubiquitin-protein ligase HERC2 under iron-replete conditions (79)

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XC: Writing original draft

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To achieve a satisfactory PDT effect in aerobic and hypoxic scenarios simultaneously, three types of red light-emissive CDs (RCDs) derived from hypericum perforatum extract with adjustable type I/II ROS production have been developed ( via surface amine groups, which interact electrostatically with the negatively charged inner mitochondrial membrane, achieving high mitochondrial colocalization