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Additionally, engineering the rhizosphere with plant growthpromoting microorganisms, combined with microbial genetic modification, has demonstrated significant potential in enhancing pesticide degradation while simultaneously improving crop growth and productivity

Moreover, increased ferroptosis is found to enhance the expression of pro-angiogenic factors vascular endothelial growth factor and IL-8 (103,104)

In patients with LBCL, researchers confirmed that those who did not achieve an early molecular response had a higher fraction of exhausted CD8 + T cells in CAR-T cell infusion products, featuring increased expression of LAG3 and TIM3 [24]

Thus, loss of mitochondrial complex III, or the downstream mitochondrial complex IV, diminishes DHODH activity, limiting de novo pyrimidine synthesis

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