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Notably, a recent study demonstrated that Ganoderic acid D overcomes gemcitabine resistance by promoting the degradation of HIF-1 driven by MDM2, which leads to a reduction in glycolysis in triple-negative breast cancer cells (Luo et al., 2024)

The first genome-scale metabolic model (GSMM) iRV973 for Candida auris predicted growth under various nutrient conditions and identified 50 conserved, serum-essential enzymessome as novel, non-homologous drug targets (Viana et al., 2023)

The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses

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The existing human studies are not adequate to establish efficacy or safety for any indication