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Daubert DM, et al

ThorenF.RomeroA.LindhM.DahlgrenC.HellstrandK.2004A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen radicals

mtDNA is continuously damaged, which can eventually lead to mutations and mitochondrial dysfunction

While there isnt much evidence of a need for this high of a dose, and 500mg is typically the perfect amount, it may still be a very strong option, especially for those who have taken glutathione for a while and are curious if a higher dose may be helpful