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doi: 10.1016/j.nutres.2020.03.005

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Finally, transcriptomic analyses were performed on key metabolic brain regions including the dorsal vagal complex (DVC), LPBN, and mediobasal hypothalamus (MBH), after 21 days of treatment

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The source of such ketone synthesis in the liver, when the body is under glucose starvation, is smart from the point of view that fatty acids themselves, originating from the bodys fat reserves, cannot cross the bloodbrain barrier and thus satisfy the brains energy needs (16, 17)