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Despite multimodal treatments, recurrence is almost inevitable, partially due to the difficulty of complete surgical removal, with a median interval of less than 10 months 6,7,8

To examine whether the chemical conjugation of MK-801 to GLP-1 mitigates the adverse hyperthermic and hyperlocomotive effects of MK-801, mice were subjected to body temperature measurements and open-field behavioural tests after chronic and acute drug administration, respectively

Absorbance was measured at 490 nm using a microplate reader (Epoch, Bio Teck, Winooski, VT, USA)

However, variation in blood pressure, as would occur over the course of 24 hours in response to various stimuli (exercise and stress), may be critical in evaluating estrogenic effects on sympathetic control (Kaplan et al., 1996

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