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For selectivity studies, recombinant GSTO1 (1 M), PDI (1 M), BSA (1 M) or GRP78 (1 M) in reaction buffer were incubated with C1-27 or DMSO for 30 min at 37 C, followed by incubation with CMFDA (500 nM), BODIPY- C1-27A (1 M) or DMSO for 30 min

3 Natural products targeting tumor metabolism Although a variety of chemotherapeutic and molecularly targeted agents have been developed to inhibit key metabolic enzymes, their clinical application is often limited by modest efficacy, drug resistance, and severe adverse effects

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The most common symptoms include fatigue, pale or yellow skin, difficulty concentrating, headaches, gastrointestinal upset, depression, and numbness or tingling in the hands or feet

Ito, F., Kato, K., Yanatori, I., Murohara, T