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In addition to the cohort studies, four meta-analyses confirmed a higher frequency of vitamin B12 deficiency in patients with T2D taking metformin [28-31]

1970 Mar 15;33(2):441-57

Layilin is critical for mediating hyaluronan 35 kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo

It is known that the activation of all TRPs promotes the entry of Ca 2+ into the cell, which, in turn, triggers the activation of biochemical pathways, such as the calcium-dependent-phospholipase C (PLC) pathway (Kouchi et al., 2004), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP 2 ) into inositol 1,4,5-trifosfato (IP 3 ) and diacylglycerol (DAG) (Wang et al., 2020) and then IP 3 binds to IP 3 receptors located in the endoplasmic reticulum (ER), promoting a transient increase in cytosolic Ca 2+ (Curcic et al., 2019

164 Oxaliplatin-induced drug-induced fatty liver disease in a tree shrew model manifests as early severe hepatocyte steatosis and ballooning, late mild steatosis with sinusoidal dilation, and persistent hepatic oxidative stress