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While the duration of drug release is limited for orally administered products by the gastrointestinal transit time (typically 1236 hr), no such limit applies to nonoral routes of administration

Specifically, activating GluN2 has been shown to initiate non-ionotropic signalling resulting in a form of LTD [37]

McCarty, D., Coleman, M

fundamental que a escovao completa contemple todos os lados do dente, usando a escova para desorganizar e remover o biofilme dental, sem esquecer de massagear as gengivas

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