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Genes, Brain and Behavior 7:506512 Lakshminarayanan B, Baek SC, Lee JP, Kannappan N, Mangiatordi GF, Nicolotti O, Subburaju T, Kim H, Mathew B (2019)

"Studies on the effects of topical glycyl-L-histidyl-L-lysine copper in various aging models." Dis Manag Clin Outcomes

The core biochemical event is the iron-dependent, cumulative peroxidation of polyunsaturated fatty acid (PUFA) chains in membrane phospholipids, ultimately leading to the physical rupture of the cell membrane (Figure 1)

Accordingly, tumor antigen specificity and tumor antigen heterogeneity are most substantial challenges faced by CART cells and BiTEs

Abbreviations ACE: angiotensin-converting enzyme ACh: acetylcholine ADMA: asymmetric dimethyl-L-arginine ATII: angiotensin II BH 4 : tetrahydrobiopterin cGKI: cGMP-dependent protein kinase cGMP: cyclic guanosine monophosphate CTP CH-I: GTP cyclohydrolase I DDAH: dimethylarginine dimethylaminohydrolase DETC: diethylthiocarbamate DHFR: dihydrofolate reductase DOCA: deoxycorticosterone acetate eNOS: endothelial nitric oxide synthase FMD: flow-mediated dilation LDL: low-density lipoprotein L-NAME: N G -nitro-L-arginine methyl ester NO: nitric oxide NTG: nitroglycerin ONOO : peroxynitrite PDE1A1: phosphodiesterase 1A1 PKC: protein kinase C PRMT: protein arginine N -methyltransferase ROS: reactive oxygen species sGC: soluble guanylyl cyclase SHR: spontaneously hypertensive rats SNP: sodium nitroprusside SOD: superoxide dismutase STZ: streptozotocin VASP: vasodilator-stimulated phosphoprotein