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Specifically, 2-O-methylation stabilizes helical regions [139, 140] and shifts the sugar pucker equilibrium toward the 3-endo conformation, which increases the overall rigidity of RNA duplexes [141, 142]

Instead, it is available as a dietary supplement, either alone or with other ingredients, and listed in the Dietary Supplement Label Database (DSLD) of the Office of Dietary Supplements (ODS), the lead federal US government entity for the scientific exploration of dietary supplements

Structural modelling of MPP-PINK1 and MPP disease mutations To further rationalize our HDX-MS results and attempt to explore how PINK1 1-45 might trap MPP dimers, we generated AlphaFold3 models of MPP in complex with either PINK1 1-45 or MDH 1-24 and mapped the HDX-MS % incorporation at 5 min on these structures to identify plausible binding modes (Fig S7A)

Endolysosomes Generic term for various types of endosomes and lysosomes

We thank to Brain KN Tsai and Richie Wang from Delta Electronics, Inc