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Description

Andrologia 53 , e13617 (2021)

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genetic mutations

The accumulation of misfolded proteins leads to severe ER stress (ERS), which activates the unfolded protein response (UPR) (Oakes and Papa, 2015)

Data were acquired using an MS3-based TMT method using the following scan parameters: scan sequence began with an MS1 master scan (Orbitrap analysis, resolution 120,000, 4001700 m/z, RF lens 60%, automatic gain control [AGC] target 2E5, maximum injection time 50 ms, centroid mode) with dynamic exclusion enabled (repeat count 1, duration 15 s)