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Mitochondrial superoxide: Production, biological effects and activation of uncoupling proteins

5 Concluding remarks and future perspectives There is mounting evidence that ferroptosis activation or inhibition has a significant impact on a variety of illnesses and could be used to treat HCC

The SLC7A11-GSH-GPX4 axis The SLC7A11-GSH-GPX4 axis constitutes the canonical defense against ferroptosis

In addition, autoantibody production is also mediated by IL-17 activation of peripheral blood mononuclear cells (PBMCs) from patients with lupus nephritis (54)

This inflammatory disruption is also evident in pathological conditions such as aGVHD, where overactivation of T cells and dysregulated cytokine production cause severe damage to the bone marrow niche, resulting in significant bone marrow suppression

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