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(Supplementary Figure S8 and Figure 2C)

Finally, MDSCs can also express immunosuppressive ligands, such as programmed death ligand-1 (PD-L1), which in turn suppresses T-cell priming and activation (151)

In particular, the pro-apoptotic phenotype is switched to the anti-apoptotic one at the level of proerythroblasts [126]

Therefore, SLC7A11 overexpression may promote tumor growth/survival but once the tumor is established, SLC7A11-high tumors are more sensitive to glucose or glutamine deficiency in the tumor microenvironment ( Figure 2 )