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Acknowledgements We thank Dr.Fuxing Dong (the Public Research Center of Xuzhou Medical University) for enthusiastic help with the laser scanning confocal microscopy experiment

Although we could not give a definitive answer to that because there was no statistically significant AE differences between group 1 and group 2, group 1 showed a numerical trend towards fewer TEAEs, fewer dropout rates due to AEs, and fewer moderate to severe AEs, suggesting that 15 mg/day dose-titration might be preferable than alternate dose titration (group 2)

61,62 The acetylation of p53 at certain sites hinders the phosphorylation of several serines located in the p53 NTD, which activates genes with high p53 affinity, including CDKN1A