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J Mol Biol 268 , 468481, (1997)

The margin between proper storage and complete product failure is narrower than most protocols acknowledge

MIC B12 Benefits and B12 With MIC Benefits: Whats Plausible vs Proven Energy and Fatigue Best-supported scenario: If you have vitamin B12 deficiency, replacing B12 can improve deficiency-related symptoms (NIH ODS provides an overview in its Vitamin B12 fact sheet )