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This dual mechanism is why tirzepatide is widely considered a breakthrough in the GLP-1 drug class

2025;4(4):Cd000547

J Clin Gastroenterol 38:S86S90 Uttra AM, Shahzad M, Shabbir A, Jahan S (2018) Ephedra gerardiana aqueous ethanolic extract and fractions attenuate Freund Complete Adjuvant induced arthritis in Sprague Dawley rats by downregulating PGE2, COX2, IL-1, IL-6, TNF-, NF-kB and upregulating IL-4 and IL-10