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Thermal equilibration was then conducted for 20 ps, gradually increasing the temperature from 100 K to 298 K using the Langevin thermostat (collision frequency of 1 ps 1 )

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Except for the (AA-dA) 2 -NH2 tail peptide, all molecules containing tails with low predicted helical propensity, had poor experimental aqueous helicity, as determined by circular dichroism spectroscopy (Table 1)