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1 10 4 cells were plated in 24-well plate and treated with TMZ and ferroptosis modulators for 72 or 120 h

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Ferroptosis pathways and therapeutic targets in spinal cord injury Targeting ACSL4/LPCAT3/15-LOX Proanthocyanidin significantly reduced ACSL4 and ALOX15 levels and increased GSH, GPX4, Nrf2, and HO-1 expression to inhibit ferroptosis and promote functional recovery from SCI (Zhou et al., 2020b)

The understanding of this mechanism was later derived from a separate study involving mice.

This mechanism makes L-carnitine especially valuable during aerobic exercise, when the body taps into fat stores for sustained energy