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Aminoacridine, abemaciclib, and proflavine notably increased expression levels of RSPO3 and RSPO4 genes, with aminoacridine notably enhancing RSPO3 levels by 19-fold, the highest among tested drugs

These charms have different chemical properties that allow them to interact in different ways w/one another (important for the protein to fold properly) & with other molecules (important for intracellular interactions)