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Cryo-EM grid preparation and data collection For the cryo-EM grids preparation, 3 l of purified ghrelin-bound complex at 13 mg/ml and GHRP-6-bound ghrelin receptor complex at 8 mg/ml were applied individually onto a glow-discharged holey carbon grid (Quantifoil, Au300 R1.2/1.3) in a Vitrobot chamber (FEI Vitrobot Mark IV)

In parallel, photoswitchable PROTACs (PS-PROTACs) achieve reversible modulation of degradation activity by integrating moieties, typically azobenzene derivatives, that undergo light-driven isomerization [146, 147]

This disruption prevents Cancer cells from synthesizing DNA and RNA, inhibiting cell division and tumor growth

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Experimental and clinical pharmacology of Andrographis paniculata and its major bioactive phytoconstituent andrographolide