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doi: 10.1111/ppl.12218 94 MurchS

The most common is mild injection site reaction (redness or itching), which typically resolves within a day

Individuals who maintain these habits often preserve much of their progress long term

[5] [6] Early-phase clinical trials including a Phase 2 trial published in the New England Journal of Medicine (2023) have reported significant reductions in body weight and improvements in metabolic markers, though this evidence remains preliminary and is not sufficient to establish a clinical dosing or reconstitution standard

However, the critical limitation remains the near-total absence of rigorous human clinical trial data