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Although the standard diagnostic approach relies on clinical data, radiological findings, and histopathology, a significant number of cases remain unclassified even after exhaustive investigations involving blood tests, advanced imaging, endoscopy, and molecular evaluation

The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1 alpha and -1 beta in macrophages

However, PBT2 did not show any significant effect on cognition

Kopetz S, Yoshino T, Kim TW, Wasan HS, Cutsem EV, Ciardiello F, Maughan TS, Eng C, Yaeger R, Desai J, Zhang X, Usari T, Mori A, Tabernero J